ea0081p604 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022
Kasarla Ramesh
, Gesmundo Iacopo
, Congiusta Noemi
, Sabbia Greta
, Pardini Barbara
, Bocchiotti Maria Alessandra
, Ghigo Ezio
, Granata Riccarda
White adipose tissue (WAT) stores excess energy as triglycerides, while brown adipose tissue (BAT) dissipates energy through heat, acting as a defence against cold and obesity and as a positive regulator of metabolic functions. BAT thermogenic functions are mainly induced by mitochondrial uncoupling protein-1 (UCP-1), which induces uptake of lipids and glucose to sustain oxidation and thermogenesis in both brown and beige adipocytes. Beige/brite adipocytes arise in WAT depots ...